I'm a biomedical science expert and published author with peer-reviewed journal publications and medical textbook authorship credentials (soft copies will be shared up on request). I've been working as a clinical trial pipeline (critical) analyst for three hedge funds since 2012. I provide independent, unbiased and ruthlessly-honest research notes on biotech (mostly drug molecules) and medtech devices (only upon request) tickers. My research notes helped my long-term clients to gain massive gains based on informed decision about the probability (success/failure) of the clinical trial pipeline in phase I, II, III and also prediction of commercial success based on the pipeline worthiness and comparative analysis with competitors. As of now, I've completed and forecast-ed the success probability of 135 tickers, with just 4 failed cases.

P.S: Due to geographical restrictions, I held no stock positions in the above said period, will not hold any stock in the foreseeable future. I'm just an independent service provider, that says all about my research notes trustworthiness.

My notes are often used by clients for long and short calls based on the pipeline worthiness.

I like shorts, as like longs, if the former's intent is to keep the market in a price-corrected manner, especially identifying the scam companies who suck the investors money before becoming bankrupt.

While I'm in search of new clients to extend my service, unfortunately, I got trapped with a habitual scamster, who is also a manipulative short.

THIS IS MY ORIGINAL SCIENTIFIC RESEARCH THAT TOOK CLOSE TO TWO WEEKS TO THOROUGHLY DEBUNK THE UNDERLYING SCIENCE OF SOLY'S RAP AND IT'S UTILITY AS AN ADJUNCT TO NANOSECOND LASER

ADAM GEFVERT (CFA???) just promised me to pay a research fee of 25%-40% initially but pocketed the short difference (30% down upon publishing the article) and resorted to scam tactics, finally ended in abusing me, upon exposure to his true color as scamster.

The scientific part published in Seeking Alpha dated was completely extracted from my research review but written in layman terms, as evidenced by the citations given in my original notes. The very scientific essence of the notes such as comparison of picosecond laser efficacy with nanosecond was given by me, by which shorted the stock up to 30% and scammed me without paying, what he promised (all emails, twitter and Skype chats are attached as screen shots in another article). The swindled portion has been highlighted in this notes, which can be compared easily. The first draft (can be seen as post of this blog) had no substantial evidence to argue the downsides of SOLY except libels, throwing abuse and individualized targeting of management, until he had my science-based research notes. He discussed the picosecond lasers elaborately in Seeking Alpha article which knew nothing about until he saw my research notes. That says about him and white diamond research scam. Those who made their subscription in his scam research entity, based on his lies, must rethink and cancel the subscription

When he post something, he relentlessly use the word 'WE'. There is no such thing as 'WE' just only 'HE'. LOL!!!

Source: Google
He is the only person who serves as a founder, manager, (bald) head analyst, front office desker and even office assistant to his 'company' which never extends more than his computer table.

Of course, he use several fake IDs to spread lies in yahoo board and twitter, which I will expose in the upcoming articles.

Stealing someone's idea to make money and dumping them sounds worse than prostitution.

My Technical/Fundamental/Pipeline analysis of SOLY:

People around the globe get tattooing the skin for fun and to show themselves as trendy. At some of point of their life, they rethink about their ink and prefer to undergo tattoo removal procedure. Aesthetic clinics typically use laser tattoo removal procedure, which has been in use since late 1960s, although the procedure cannot achieve the best treatment results due to destruction of nearby tissues and cause scarring.

For aesthetic tattoo removal, the type of laser and optimal wavelength largely depends on the patient’s tattoo color and skin type. Laser-induced breakdown of tattoo particles leads to clearing of tattoo colors from the skin and subsequent tattoo removal by body’s immune mechanism. Among various versions of laser tattoo removal procedure, shorter-pulse duration lasers are preferred by the skin beauty clinicians to remove the tattoo. The shorter-pulse duration lasers are mainly of two types such as nanosecond and picosecond range lasers, besides uncommon use of ultra-short pulsed lasers such as femtosecond laser. However, the age of the tattoo play a key role in the treatment course and outcomes.

Ultra-short laser pulse interact with the target such as tattoo inks in a focused manner within a well-defined area with limited heat conduction, causing minimal mechanical and heat damage to the ablated target area. In contrast, longer pulse duration lasers such as nanosecond lasers continuously irradiate the tattoo inks and cause heat and mechanical damage (to the target area or tattooed skin) with heat conduction outside the target area (lack precision targeting of tattoo), resulting in unaesthetic appearance of the post-treatment skin.

Some of the commonly employed lasers are Q-switched (QS) lasers including QS-Ruby, QS-Alexandrite, QS Nd:YAG etc for effective tattoo removal. Recently, picosecond lasers with a wide range of wavelength including 532-1064nm devices are being used effectively for tattoo removal. Among these, Nd:YAG 1064-nm laser can cause lower risk of scarring, epidermal damage and hypopigmentation. Laser procedures are generally beneficial to remove black, green, brown and dark blue but difficult to clear light blue, red, yellow and orange colors.

For optimal tattoo ink particle removal, shorter pulse lasers such as picosecond lasers are preferable, as it can prevent the tattoo ink particles (present in the skin) from cooling back (thermal relaxation time), which takes typically less than ten nanoseconds. Picosecond lasers (10^-12 s) achieve better tattoo ink targeting and clearance, causing least damage to surrounding tissues and treatment-related pain. However, nanosecond lasers with Q-Switched technology (10^-9 s) can produce short duration light pulse but cannot completely clear up the tattoo colors, causing damage to the targeted and nearby skin area, which is undesirable. Theoretically, pulse durations shorter than nanoseconds can allow more effective fragmentation of tattoo particles, affirming the efficacy of picosecond pulses than nanosecond pulse lasers.

Cosmetically speaking, lasers are not completely effective for tattoo removal, as the tattoo ink can go deep inside the cells and only the tattoo color present on the upper surface of the skin can be removed, while the underneath particles remain untouched. Some of the causes for laser treatment failures include the chemical and structural properties and depth of the pigment and also absorption spectrum of the tattoo color.

Recently, Soliton Inc has been investigating the combined efficacy of Rapid acoustic Pulse (RAP) device (acoustic shock wave) to accelerate the speed of tattoo removal, when used complimentarily with nanosecond lasers. SOLY believes, combined therapy may deliver the desired results within 2-3 treatments, compared to 10-12 sittings in laser-alone treatments. SOLY’s RAP device is said to blast away the ink clusters hidden under the skin, which could be further removed by subsequent laser treatment. As of now, no concrete evidence is available to demonstrate – RAP can aid complete removal and similar level of efficacy can be achieved for all colors.

In both clinical trials, SOLY has not revealed whether it is a nanosecond or picosecond laser, upon reviewing the SOLY patent, we found - it is a nanosecond 1064 nm Q-switched Nd:YAG laser, which is not as effective as picosecond laser in tattoo removal as well as for other cosmetic procedures. Upon reviewing the patent of SOLY, related to rapid pulse electrohydraulic shockwave generation revealed – SOLY’s therapeutic approach is a nanosecond laser approach not picosecond, which is inferior to picosecond laser and so are the comparative treatment benefits.

Despite these problems, SOLY has filed for 510(k) premarket clearance with USFDA for its first generation RAP tattoo removal device, indicated as an accessory to the 1064 nm Q-Switched laser for black ink tattoo removal on the arms, legs and torso in Fitzpatrick skin type I-III individuals.
Our contention is - Acoustic shock wave therapy (RAP) is good ONLY if employed with picosecond laser instead of Q-switched (nanosecond) lasers, as the latter cannot provide effective results than the former. Our notion has been confirmed by recent research study that concluded - employing picosecond laser with RAP may provide better tattoo ink clearance without causing pain or skin damage.

Why Picosecond laser is better than Nanosecond Q-Switch laser?

For several decades, Q-Switch (QS) nanosecond pulse lasers are the mainstay approach for tattoo removal but recently, the picosecond pulse technology has been developing as an effective strategy with lower rate of adverse events. Compared to other QS lasers, 1064 nm QS lasers 1064 with a variable spot size significantly demonstrated more tattoo pigment clearance causing less heat damage to the treated and nearby skin. However, irreversible ink darkening and skin discoloration can occur during the use of QS neodymium (Nd):YAG (1064 nm), possibly due to certain chemical and heat reactions (endothermic steam-carbon reaction). The risk of paradoxical darkening of tattoo ink depends on the physical characteristics of the lasers such as wavelength, fluence and pulse duration. Due to high energy, the risk of causing tattoo ink darkening is higher in nanosecond-pulsed lasers including QS Nd:YAG laser treatment (SOLY’s RAP is intended to use with 1064 nm nanosecond pulse laser).

Even with laser treatment, some colors are resistant to laser treatment or cause skin darkening after laser treatment. When it comes to removal of black pigmented tattoos, picosecond lasers are more than two folds effective and several folds effective for multi-colored tattoos and previously difficult-to-remove tattoo colors (with less hyperpigmentation), compared with QS nanosecond pulse domain lasers, which is noteworthy. This benefit is likely due to the shorter laser pulse, which is more effective for breakdown of tattoo particles (selective photothermolysis) generally sized between 10-100 nm, and has a thermal relaxation time of 0.1-10 nanoseconds. Further evidences suggest – picosecond domain lasers are safer and effective for tattoo removal.

Statistically significant superiority of picosecond lasers has been demonstrated for tattoo clearance with lesser treatment-related pain, compared to nanosecond laser. Picosecond pulse lasers significantly cleared 12 of 16 tattoos with more clearance effect on black tattoos than nanosecond lasers. Higher efficacy in tattoo ink clearance observed in picosecond lasers than nanosecond domain lasers was possibly due to pulse duration and fluences of less magnitude (short pulses selectively disrupt skin cells containing tattoo colors).

A laboratory animal study that compared various versions of nanosecond and picosecond lasers (QS Nd:YAG and Alexandrite lasers) reported – disregard of pulse duration (picosecond or nanosecond), 532-nm laser was found to be effective for clearing yellow, red and orange pigments (overall efficacy and safety was better in 532-nm picosecond laser) and picosecond 1064-nm laser demonstrated moderate effects on non-black colored tattoos. In terms of safety and efficacy, picosecond lasers were found to be better than nanosecond lasers. According to one study – the wavelength is more influential than pulse duration for removal of tattoo pigments. Among all the lasers, picosecond 532 nm lasers was found to be overall effective and 1064 nm laser was most effective for black tattoo removal with lesser skin scarring due to low fluence level. The physical effects of lasers appear to be involved in the fragmentation of tattoo inks, especially in picosecond lasers that cause ‘bubble-like cavitation’ and subsequent tattoo ink removal.

The effective removal of certain tattoo colors requires certain wavelengths of lasers.

For removal of blue and/or green pigments, 755 nm picosecond Alexandrite laser as an effective and rapid treatment option, without causing collateral injury to nearby tissues. While employing picosecond pulse lasers, 75% tattoo clearance can be achieved after initial treatment and the rest within 1 or 2 treatments.

To our surprise, one study reported – extremely rapid and successful removal (75-100%) of 12 green and/or blue tattoos using 755-nm Alexandrite laser picosecond with acoustic shock wave therapy, with just 1 or 2 treatments. What we should note is – the study (as well as other studies) employed picosecond laser NOT nanosecond laser, which may produce comparatively lesser efficacy, which will happen in the case of SOLY’s RAP with QS nanosecond laser.

To remove a tattoo particle that sized 40-nm-diameter, a 35- picosecond pulse duration laser can deposit adequate energy on the 40-nm sphere in a precisely-focused manner, which cannot be achieved by 10-nanosecond pulse due to significant heat transfer in the surrounding medium. These findings were confirmed by microscopic studies that observed greater microscopic depth of scattered pigment (fragmented) following the picosecond laser exposure. More altered tattoo particles is associated with gross and enhanced tattoo clearance, in addition to tattoo ink-laden skin cell death and/or intrinsic ink particle changes. These findings were further confirmed by another study.

According to independent studies, after three treatment sessions, nearly 80% clearance of the tattoo was observed in acoustic shock wave therapy, compared with 60% clearance in picosecond 1064-nm Nd:YAG laser and perfluorodecalin (PFD) patch alone. Better safety profile was observed in acoustic shock wave therapy than laser treatment arm. Concurrent treatment of RAP with picosecond laser may lead to breakdown of tattoo colors in the target area with increased color removal by the body’s scavenging mechanisms in the target area without causing significant side effects.

Source: Seeking Alpha

Taken together, combining RAP with lasers is beneficial only if combined with picosecond lasers, rather than employing Q-Switch nanosecond lasers, which SOLY has been investigating.

Although, lasers are being considered as a gold standard for tattoo removal, employing appropriate technique and device does not always guarantee the desired treatment outcome. The successful tattoo removal depends on several factors including type of tattoo and employed tattoo color and also the depth of the tattoo color, in addition to wavelength and the fluence of the laser. In some cases, laser tattoo removal resulted in more tattooing and unaesthetic appearance. The discrepancies in the efficacy and satisfactory response in tattoo removal is still being studied but poorly understood. Despite these reported benefits, the art of tattoo removal is still unable to achieve complete perfection or desired treatment outcomes, which is noteworthy.

For other indications (to be considered in future by SOLY) such as treatment of skin hyperpigmentation (melasma) and other pigmented nevi, the definitive and conclusive evidences are scanty (even for picosecond lasers).

Upon looking into the side effects of QS lasers, some studies reported - colour shift (post-treatment skin pigmentation) following tattoo removal with QS Nd-YAG laser (1064/532) as an adverse event, most frequently with white/flesh colored pigments but also with other colors including crimson, brown, red and yellow pigments. This is something SOLY has not revealed anywhere as an adverse event.

SOLY’s Rapid Acoustic Pulse (RAP) for cellulite treatment:

Not just tattoo removal - SOLY has been zeroing on cosmetic and aesthetic niche, particularly cellulite removal.

Cellulite is a skin condition characterized by presence of dimpled and lumpy skin appearance, mostly present in thighs and buttocks. Cellulite occurs due to fat deposits that push the connective tissues beneath the skin structure, leading to unaesthetic skin appearance. Cellulite is common in women than men; naturally, women like smooth-textured skin and prefer to undergo cellulite treatment.

SOLY’s RAP is an acoustic shock wave therapy, also called as Extracorporeal Shock Wave Therapy (ESWT). Research studies suggest – ESWTs such as RAP may restructure the skin properties and subcutaneous tissues and thus improve the aspects of cellulite and localized fat. Scientists have shown that low-energy, defocused ESWT can remodel the collagen, present beneath the skin and possibly treat cellulite.

Similar to cellulite, RAP can also be employed to reduce the circumference and fat thickness of the thighs without causing any side effects.

Research studies confirmed the positive effects of acoustic waves on living tissues via stimulation of blood circulation in small blood vessels and also improvement of cell membrane permeability and elasticity. The treatment might be comparatively effective for elderly people with prolonged clinical history of cellulite, than others.

According to an independent study’s conclusion - although, radial shock wave therapy is safe and effective for cellulite treatment, and the individual clinical outcome cannot be predicted due to patient’s or individual’s cellulite grade at the time of treatment initiation, height or age, weight and individual’s body mass index (all these parameters can vary from one person to another, so are the results). Meaning - the treatment benefit CANNOT be generalized for all cellulite cases.

These findings were mirrored by another review study that included 7 research review studies and 66 original research studies to analyze the efficacy of some of the non-invasive body contouring devices including ESWT (RAP). Upon critically reviewing all these studies, the researchers concluded that – the clinical or beneficial effects of all these non-invasive body contouring devices (including ESWT) are mild to moderate for cellulite treatment.

It is important to note ESWT is similar to SOLY’s RAP or acoustic pulse therapy and SOLY has been maintaining that – RAP is a very effective treatment option for cellulite removal, while these independent studies report mild to moderate efficacy, which we can see as a significant discrepancy.

Source: Seeking Alpha

Instead of single approach with shock wave therapy or RAP treatment, combined treatment regimens such as suction, cryolipolysis, manual massage etc can be preferentially employed for effective cellulite removal.

If SOLY consider these combined techniques, the results might be improved, although, reliable evidences are limited in this field.

However, studies have suggested that – the treatment effect begins delayed and can be first seen only AFTER 5 treatments. The improvement increases continuously up to 3 months.

Please note: SOLY has been maintaining RAP is effective but did not disclose the possibility of delayed treatment benefits, possibly SOLY might have observed in the animal study results.

Additionally, the adverse events associated focused/pulsed ultrasound procedure is often unreported. Recently, four cases of burns were reported while patients underwent this procedure, and hence the risk of such adverse events during SOLY’s RAP treatment cannot be ruled out, despite such incidences are underplayed by SOLY.

Unknown and possible side effect of rapid acoustic pulse:

While most of the studies deny the risk the moderate to serious adverse events related to shock wave therapy, recently one study that examined the efficacy and safety of ESWT for cellulite reported the possible risk of causing birth defects in unborn child upon exposure (teratogenicity) to ESWT. The same study found a dose-dependent increase in the degree of embryo damage, upon shock wave exposure, resulted in birth defects in the fetus.

Although, these findings were based on laboratory animal studies, the potential of shock waves to reach the unborn embryo of a pregnant woman (undergoing cellulite treatment) could harm the unborn fetus in her womb.

Source: Seeking Alpha

Taken together, shock wave therapy or RAP treatment should not be considered something like ‘vibrating massage therapy’ for cellulite treatment but should be considered as a moderate risk treatment procedure and pregnancy must be ruled out before RAP exposure to avoid serious harm.

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THIS WILL BE NOTIFIED TO SEEKING ALPHA AS WELL AND A COPYRIGHT AND AUTHORSHIP ISSUE WILL RAISED. OF COURSE, THIS BLOG LINK WILL REACH THE INVESTORS' COMMUNITY VIA ALL MEANS OF TRANSMISSION.